SELKO AOmix

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Support cattle performance by steering oxidative status with more bioavailable antioxidants from Selko AOmix

Figure 1. Antioxidants in Selko AOmix function throughout the cell

Figure 2. In-vitro assessment of antioxidative equivalence of Selko AOmix vs. synthetic vitamin E-50 using the KRL method (kit radicaux libres), showing that Selko AOmix has 5 times higher antioxidative capacity per weight unit.

The role of Selko AOmix in combating oxidative stress

Oxidative stress in cattle can cause various health problems, including reduced growth, immune function, and reproductive performance. To mitigate oxidative stress in cattle, it is important to provide a balanced diet with adequate levels of antioxidants. The effectiveness of antioxidants depends on factors such as their bioavailability and solubility. To address these concerns, specially formulated alternatives to vitamin E for cattle, such as Selko AOmix, have been developed. These alternatives provide optimal digestibility and cover the complete water-to-fat-soluble range, ensuring the delivery of antioxidants to every part of the cattle's cells.

Crucial factors in antioxidant effectiveness

  • Good bioavailability for optimal absorption: if the supplement is not well-digested, fewer antioxidants are made available. The bioavailability of antioxidants depends on the absorption and the distribution in the cells.
  • Another factor in an antioxidant’s effectiveness is its water vs. fat solubility, which can vary widely. Solubility is what determines where antioxidants are distributed in the body. Vitamin E for cattle, for instance, mainly delivers its antioxidant effect at the cell membrane, and has less impact on the internal or external cell environment (Figure 1).

Ruminants and monogastrics have different digestive systems. Therefore, the antioxidants offered to them differ in bioavailability. In ruminants, bioavailability is directly linked to the polyphenol’s susceptibility to fermentation in the rumen, the type of fermentation products produced, and the bioavailability of bypass polyphenols of polyphenol fermentation products. Based on that knowledge, Selko formulated ruminant specific alternatives to partially replace vitamin E for cattle. Plant extracts were selected which either contain bypass polyphenols or which are fermented into potent and bioavailable polyphenols. The resulting product is Selko AOmix and is capable of substituting and/or complementing the antioxidant protection that most cattle currently get from Vitamin E supplemented above requirements (Figure 2).

Selko AOmix: A cost-effective solution to partially replace vitamin E for cattle

Administration

The natural polyphenols in Selko AOmix range from water-soluble to biphasic (soluble in both water and fat) to fat-soluble, ensuring antioxidant support throughout the cellular environment.

In a feed formulation, Selko AOmix can partially replace more expensive antioxidant ingredients such as cattle vitamin E supplemented above requirements. Due to the optimal bioavailability and distribution characteristics, polyphenols can support the immune system, fertility, and offspring antioxidant status.

Typical Vitamin E levels in practice. Vitamin E requirement + antioxidant function Minimum vitamin E requirement NASEM Amount of replaceable vitamin E for antioxidant purpose Vitamin E antioxidant function replacement with Selko AOmix*
Calculated with a BW of 650kg IU/day
Dry cows 2100 1100 1000 250
Prepartum cows within 3 weeks of calving* 3000 2000 1000 250
Lactating dairy cows and heifer 1100 550 450 113
*1 unit of Selko AOmix for ruminants (commercial name:
Selko AOmix R) can replace 4 units of synthetic vitamin E-50

Selko | solutions based on science

Increase your milk production by improving fibre digestibility

Contact your local Selko IntelliBond representative for more information

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Selko | Solutions based science

Manage hindgut health to maintain dairy performance with Selko® LactiBute.

Contact your local Selko specialist
for a free consult.

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Selko® | sharing latest scientific insights

Check the quality of your TMR
with a free TMR pathogen screening

Protect cow health and milk production with a complementary TMR pathogen screening worth €100. Early detection of contamination maintains herd performance. Contact us to claim your analysis.

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Features

The natural antioxidants in the specially formulated Selko AOmix blend has not only been selected for ideal digestibility, it also covers the complete water-to-fat-soluble range to ensure optimal antioxidant activity in every part of the cell.

Benefits

Antioxidants in Selko AOmix mitigate the damaging effects of free radicals. Thereby supporting performance under challenging conditions like heat stress and the immune system and general health status. Selko AOmix can save costs by replacing the more expensive vitamin E levels exceeding NASEM recommendations (metabolic requirements) for antioxidant purposes.

Download research and documentation

You can access all of our documentation such as the science behind Selko research documents, Selko technical bulletins about transition management and technical product data sheets or feeding schedules.

Polyphenols: a cost-effective solution to partially replace vitamin E

Discover the hidden threat of oxidative stress, a natural byproduct of metabolism, and how it affects your cattle's well-being. Download our product brochure to find innovative solutions to protect your herd from oxidative stress, ensuring their vitality even in challenging conditions like heat stress, high-concentrate diets, and health issues. Safeguard your cattle's health with Selko's proven solutions.

Or visit our download center for more information:

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