SELKO AOmix

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Selko | AOmix

Support cattle performance by steering oxidative status with more bioavailable antioxidants from Selko AOmix

Figure 1. Antioxidants in Selko AOmix function throughout the cell

Figure 2. In-vitro assessment of antioxidative equivalence of Selko AOmix vs. synthetic vitamin E-50 using the KRL method (kit radicaux libres), showing that Selko AOmix has 5 times higher antioxidative capacity per weight unit.

The role of Selko AOmix in combating oxidative stress

Oxidative stress in cattle can cause various health problems, including reduced growth, immune function, and reproductive performance. To mitigate oxidative stress in cattle, it is important to provide a balanced diet with adequate levels of antioxidants. The effectiveness of antioxidants depends on factors such as their bioavailability and solubility. To address these concerns, specially formulated alternatives to vitamin E, such as Selko AOmix, have been developed. These alternatives provide optimal digestibility and cover the complete water-to-fat-soluble range, ensuring the delivery of antioxidants to every part of the cattle's cells.

Crucial factors in antioxidant effectiveness

  • Good bioavailability for optimal absorption: if the supplement is not well-digested, fewer antioxidants are made available. The bioavailability of antioxidants depends on the absorption and the distribution in the cells.
  • Another factor in an antioxidant’s effectiveness is its water vs. fat solubility, which can vary widely. Solubility is what determines where antioxidants are distributed in the body. Vitamin E, for instance, mainly delivers its antioxidant effect at the cell membrane, and has less impact on the internal or external cell environment (Figure 1).

Ruminants and monogastrics have different digestive systems. Therefore, the antioxidants offered to them differ in bioavailability. In ruminants, bioavailability is directly linked to the polyphenol’s susceptibility to fermentation in the rumen, the type of fermentation products produced, and the bioavailability of bypass polyphenols of polyphenol fermentation products. Based on that knowledge, Selko formulated ruminant specific alternatives to partially replace vitamin E. Plant extracts were selected which either contain bypass polyphenols or which are fermented into potent and bioavailable polyphenols. The resulting product is Selko AOmix and is capable of substituting and/or complementing the antioxidant protection that most cattle currently get from Vitamin E supplemented above requirements (Figure 2).

Selko® | sharing latest scientific insights

"Cattle feed composition is a promising way to reduce methane gas emissions"

Join Dr. E. Kebreab on our next webinar, Friday May 26 2023: "Effective strategies to reduce the carbon footprint of dairy cattle"

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Selko® | sharing latest scientific insights

"Cattle feed composition is a promising way to reduce methane gas emissions"

Watch the recordings of Dr. E. Kebreab's webinar and learn how to reduce methane emissions and reduce the carbon footprint of dairy cattle. Learn why he endorses IntelliBond as a methane reducing feed additive.

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Selko AOmix: A cost-effective solution to partially replace vitamin E

Administration

The natural polyphenols in Selko AOmix range from water-soluble to biphasic (soluble in both water and fat) to fat-soluble, ensuring antioxidant support throughout the cellular environment.

In a feed formulation, Selko AOmix can partially replace more expensive antioxidant ingredients such as vitamin E supplemented above requirements. Due to the optimal bioavailability and distribution characteristics, polyphenols can support the immune system, fertility, and offspring antioxidant status.

Typical Vitamin E levels in practice. Vitamin E requirement + antioxidant function Minimum vitamin E requirement NASEM Antioxidant function of vitamin E replacement by Selko AOmix
Calculated with a BW of 650kg IU/day
Dry cows 2100 1100 1000
Prepartum cows within 3 weeks of calving* 3000 2000 1000
Lactating dairy cows and heifer 1100 550 550
*By NASEM ideal but less common in practice. Vit. E could be used to supply the 1100IU/day with Selko AOmix added on top to bridge some of the gap between pre-fresh and close up.

Features

The natural antioxidants in the specially formulated Selko AOmix blend has not only been selected for ideal digestibility, it also covers the complete water-to-fat-soluble range to ensure optimal antioxidant activity in every part of the cell.

Benefits

Antioxidants in Selko AOmix mitigate the damaging effects of free radicals. Thereby supporting performance under challenging conditions like heat stress and the immune system and general health status. Selko AOmix can save costs by replacing the more expensive vitamin E levels exceeding NASEM recommendations (metabolic requirements) for antioxidant purposes.

Selko | solutions based on science

Increase your milk production by improving fibre digestibility

Contact your local Selko IntelliBond representative for more information

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Selko | Solutions based science

Manage hindgut health to maintain dairy performance with Selko® LactiBute.

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for a free consult.

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Download more research and documentation

You can access all of our documentation such as the science behind Selko research documents, Selko technical bulletins about transition management and technical product data sheets or feeding schedules.

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