SELKO TOXO-XXL

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Selko TOXO-XXL

Mitigating the effect of newly emerging mycotoxins on dairy performance with Selko-Toxo XXL

Newly emerging mycotoxins of dairy cows are causing problems with dairy cow performance

New mycotoxins are emerging in dairy cattle. Farms surveys in which samples are tested for multiple mycotoxins show that at least one mycotoxin is present in almost all samples of feed for dairy cows. These newly emerging mycotoxins can have a neagtive effect on rumen function and gut health of dairy cows, which means that a mycotoxin mitigation product for ruminants should bind mycotoxins in the rumen, but should also reduce absorbtion of mycotoxins into the bloodstream and deal with the systemic inflammation that can be the result of a challenge with mycotoxins in dairy cows.

Mitigating the negative effects of newly emerging mycotoxins on performance of the dairy herd

A mycotoxin management programme should include:

  • Early identification of contaminated feed stuffs for dairy cows
  • Crop management programmes that to reduce growth of molds, while the crops are still on the field but also during storage
  • Adding mold inhibitors and silage inoculants while crops are being ensiled
  • The use of mold inhibitors such as Selko TMR, these mold inhibtors should be sprayed on the face of the silage after cutting
  • Feeding mycotoxin mitigation products for dairy cows in case feed ingredients contaminated with mycotoxins can't be avoided completely

Selko® | sharing latest scientific insights

"Cattle feed composition is a promising way to reduce methane gas emissions"

Join Dr. E. Kebreab on our webinar, Friday May 26 2023: "Effective strategies to reduce the carbon footprint of dairy cattle"

You can no longer register for this webinar. A video recording of the webinar will be made available soon.

Selko® | sharing latest scientific insights

"Cattle feed composition is a promising way to reduce methane gas emissions"

Join Dr. E. Kebreab on our next webinar, Friday May 26 2023: "Effective strategies to reduce the carbon footprint of dairy cattle"
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Selko® | sharing latest scientific insights

"Cattle feed composition is a promising way to reduce methane gas emissions"

Welcome back and thank you for registering for our upcoming webinar, Friday May 26 2023!

We are excited to have you join our informative and engaging session. To access the webinar page, kindly click the link below. We look forward to sharing our latest scientific insights with you during this event.
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Selko Toxo-XXL

Selko Toxo-XXL

Selko Toxo®-XXL contains bentonite, a mycotoxin binder with at least 50% smectite, which has strong binding capacity for aflatoxins, ergot toxines and LPS. It also contains glucose biopolymers that stimulate gut barrier function of dairy cattle, purified β-glucans that improve the immune function of dairy cows and anti-oxidants that reduce the effect of systemic inflammation in dairy cattle. In addition to preventing the mycotoxins from binding, Selko Toxo-XXL also improves rumen and gut health, stimulates the immune system and reduces oxidative stress.

Administration

Selko Toxo-XXL for ruminants is presented as a dry powder. The recommended dose is based on the level of mycotoxins in the dairy ration and is 15 to 45 g per head per day:

  • in case of low mycotoxin toxicity: 15 g
  • In case of medium mycotoxin toxicity: 30 g
  • In case of high mycotoxin toxicity: 45 g

Selko | solutions based on science

Increase your milk production by improving fibre digestibility

Contact your local Selko IntelliBond representative for more information
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Selko | Solutions based science

Manage hindgut health to maintain dairy performance with Selko® LactiBute.

Contact your local Selko specialist
for a free consult.
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Efficacy trial with Selko Toxo-XXL in dairy cows challenged with ZEA, DON and FUM Fusarium mycotoxins

Material and methods

Little is known about the adverse effects of commonly found levels of Fusarium mycotoxins on dairy cow performance, especially after a long period of exposure to feed contaminated with mycotoxins. A trial was carried out by professor Gallo from the University of Piacenza in Italy in which efficacy of Selko Toxo-XXL against 3 different Fusarium mycotoxins of diary cattle was tested. A total of 31 lactating Holstein cows were included in the study and they were exposed to the 3 different fusarium mycotoxins for a period of 54 days. There was a group that was exposed to low levels of fusarium mycotoxins, a groups exposed to high levels of fusarium mycotoxins and a group that was exposed to high levels of fusarium mycotoxins and treated with Selko Toxo XXL:

  • Negative control group: TMR with low levels of DON, ZEA and FUM, at 284.5, 43.2 and 129.6 µg/kg dry matter, respectively
  • Positive control group: TMR high levels of DON, ZEA and FUM at 1021.0, 196.8 and 238.4 µg/kg dry matter, respectively
  • Selko Toxo-XXL group: TMR also with high levels of DON, ZEA and FB at 1009.6, 248.5 and 241.7 µg/kg, respectively, and supplemented with 100 g/cow/day of Selko Toxo-XXL. Dry matter intake, milk production and milk solids were compared between the 3 groups. Milk coagulation propperties (rennet coagulation time, curd firmness traits and curd firmness 30 min after enzyme addition) were measured to test suitability of the milk for cheese production.

Figure 1: Dry matter intake (DMI) of dairy cows, expressed as percentage relative to the initial bodyweight, in negative controls on a diet with low levels of DON, ZEA and FUM mycotoxins (CTR), positive controls on a diet with high levels of DON, ZEA and FUM mycotoxins (MXT) or dairy cows on a diet with high levels of DON, ZEA and FUM mycotoxins in combination with treatment with Selko Toxo-XXL.

Results, dry matter intake of dairy cows

Contamination of the feed with high levels of Fusarium mycotoxins resulted in a reduction of dry matter intake of dairy cows (see Figure 1). Treatment with Selko Toxo-XXL resulted in an increase of dry matter intake, compared to both the dairy cows exposed to low levels of Fusarium mycotoxins and the dairy cows exposed to high levels of Fusarium mycotoxins.

Figure 2: Rumination time of dairy cattle in minutes per day of negative controls on a diet with low levels of Fusarium mycotoxins (CTR), positive controls on a diet with high levels of Fusarium mycotoxins (MXT) or dairy cattle on a diet with high levels of Fusarium mycotoxins in combination with treatment with Selko Toxo-XXL.

Results, rumination time of dairy cows

Rumination time of dairy cows is indicative of rumen function. Contamination of the dairy feed with high levels of ZEA, DON and FUM mycotoxins resulted in a reduction of rumination time in the dairy cows included in the study (see Figure 2). Treatment of dairy cows with Selko Toxo-XXL resulted in an increase of rumination time compared to both the dairy cows exposed to low levels of ZEA, DON and FUM mycotoxins and the dairy cows exposed to high levels of ZEA, DON and FUM mycotoxins.

Figure 3: Production of Energy Corrected Milk (ECM) of dairy cows on a diet with low levels of Fusarium mycotoxins (CTR), dairy cows on a diet with high levels of Fusarium mycotoxins (MXT) or dairy cows on a diet with high levels of Fusarium mycotoxins in combination with treatment with Selko Toxo-XXL for ruminants.

Results, milk production and quality of milk for dairy cheese production

The production of energy corrected milk (ECM) of the dairy cattle included in the study was reduced in the dairy cows on a diet with high levels of Fusarium mycotoxins, compared to the negative control cows fed the diet with low levels of Fusarium mycotoxins. The dairy cattle treated with Selko Toxo-XXL produced more milk compared to both the negative control cows on a diet with low levels of Fusarium mycotoxins and the positive control group on the cattle diet with high levels of Fusarium mycotoxins (see Figure 3). Concerning milk quality, the milk fat concentration tended to be lower in negative control cows fed the diet with low levels of Fusarium mycotoxins compared to the dairy cows fed the diet with high levels of Fusarium mycotoxins and the group of dairy cows treated with Selko Toxo-XXL (3.52% vs. 3.74% and 3.80 %, respectively). Milk coagulation properties of the milk of dairy cows treated with Selko Toxo-XXL were comparable to the milk coagulation properties of the milk from dairy cows exposed to low levels of Fusarium mycotoxins and improved compared to the milk coagulation properties of milk from the cows exposed to high levels of Fusarium mycotoxins.

Conclusion of the trial with Selko Toxo-XXL in dairy cattle

Selko Toxo-XXL mitigated the effects of a challenge of dairy cattle with high levels of deoxynivalenol (DON), zearalenone (ZEA) and fumonisins (FUM). Treatment of dairy cattle with Selko Toxo-XXL resulted in an increase of dry matter intake (DMI and an increase in rumination time, suggestive of a better rumen function of the dairy cows included in the study. Selko Toxo-XXL also mitigated the negative effects of the mycotoxin challenges on dairy milk production. Treatment of dairy cattle with Selko Toxo-XXL increased the production of ECM by 1.88 litre//cow/day. The effects of fusarium mycotoxins on the suitability of milk for cheese production were mitigated by Selko Toxo-XXL.

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Read more about what Selko LactiBute can do for you...

Selko | Transition Management

Rumen protected calcium gluconate increases average daily gain of beef cattle by 95 grams per day

Selko LactiBute improves hindgut health and reduces systemic immune activation in cattle. As a result, starch levels in the faeces decline, faecal pH increases and averag daily gain of beef cattle fed Selko LactiBute is improved by 95 grams/day.

Selko | Transition Management

Feeding rumen protected calcium gluconate increases milk production on 2 dairy farms in Poland

Selko LactiBute improves hindgut health and reduces systemic immune activation. As a result, energy partition improves and more energy is available for the dairy cow to produce milk. A trial with Selko LactiBute for dairy cattle was carried out in Poland. Selko LactiBute increased milk production by 2.77 kg per cow per day.

Selko | Transition Management

Rumen protected calcium gluconate increases milk production of dairy cows on 3 commercial farms in France

A trial with Selko LactiBute in dairy cattle was carried out on 3 dairy farms in France. Milk production of cows treated with Selko LactiBute was compared to the predicted milk production based on genetic potential of the herd. Selko LactiBute improved persistence of milk production. Before the start of the trial, milk production in all 3 dairy herds was equal to the genetic potential of the dairy cows in the herd. During the 4 month period that the cows were on Selko LactiBute, differences in milk production of up to 2.7 kg of milk per day were observed.

Selko | Transition Management

Calcium gluconate increases production of energy corrected milk in dairy cows

Selko LactiBute was tested in 6 Dutch commercial dairy farms. Compared to controls and compared to their genetic potential, dairy cows fed Selko LactiBute had an increase of ECM production of 0.8-1 kg.

Selko | Transition Management

The impact of calcium gluconate on volatile fatty acid levels in the hindgut of cattle

A trial in cattle showed that Selko LactiBute, containing rumen protected calcium gluconate had a prebiotic effect in the hindgut of cattle. This resulted in increased levels of acetate and propionate and a trend towards higher levels of butyrate in the hindgut. Butyrate can reduce the risk of hindgut acidosis in dairy cows.

Selko | Transition Management

Dietary interventions to improve hindgut health of dairy cows

During the transition to lactation, dairy cows have to undergo metabolic adaptation, digestive adaptation and immune adaptation. Recent advances in ruminant nutrition highlight the importance of hindgut health as a prerequisite for a smooth digestive adaptation.

Selko | Health and Fertility

Systemic inflammation as a result of heat stress reduces performance of dairy cows.

Rising feed costs and the cost of producing forage are presenting a major challenge to dairy farmers. Improving feed efficiency is therefore crucial to ensure dairy farm profitability. Heat stress is becoming more common. It results in a reduction of dry matter intake in combination with systemic inflammation as a result of “leaky gut”.

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Selko | Sustainable Dairy Farming

Managing the ration of dairy cows before they are turned out to pasture

Keep dairy cows milking as well as possible with high milk quality when they hit spring grass. Ensure dairy cows are pregnant and that calving intervals of dairy cows are not dragging out as this will have implications for the next lactation. Keep cows healthy and ensure they are not lame, making them ready to graze. Find out more about tuning the diet of a dairy herd at turnout.

Selko | Transition Management

Beyond the rumen of dairy cattle

Feed restriction and heat stress might can cause hind gut acidosis and "leaky gut" in dairy cows. Nutritional strategies can help mitigate the effects of leaky gut in dairy cows. Zinc can reduce oxidative stress in dairy cows and can also improve the immune response. Hydroxy chloride trace minerals have a higher bio-availability than sulfate-based trace minerals. The increased amounts of zinc available to the dairy cow supports better enterocyte health and reduces bacterial infiltration and the occurrence of systemic inflammation in dairy cows.

Selko | Dairy Performance

The impact of trace mineral management on rumen function of dairy cows

During the EAAP congress, Professor Spears will discuss research that indicates that hydroxy sources of Zn and Cu are metabolized differently in the rumen than sulfate sources. This have an impact on fiber digestibility of dairy cattle.Limited research suggests that trace mineral source may affect the rumen microbiome of dairy cows.

Selko | Dairy Performance

Making dairy farming sustainable by improving digestibility of fibre in dairy cattle

Feed effciency of dairy cows can be used to measure performance, to monitor income over feed costs and to reduce the amount of methane produced per kg of milk. Digestibility of feed has a big impact on feed efficiency. Fibre digestibility can be improved by using hydroxy trace minerals instead of sulphates.

Selko | Dairy Performance

The impact of trace mineral source on fibre digestibility and milk production of dairy cows

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The impact of trace mineral source on palatability of calf starter

Compared to hydroxy trace minerals for dairy cattle, suplhate trace minerals are highly soluble and as a result, can have a strong negative impact on palatbility of cattle feed.

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Managing trace minerals for ruminants under bad weather conditions

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Selko | Dairy Performance

Three reasons to rethink sulphate trace minerals in the ration of dairy cows

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Selko | Health and Fertility

The impact of trace mineral management on reproductive performance of cows

Fertility is an important driver of dairy farm profitability. Poor fertility can significantly reduce the lifespan of dairy cows. IntelliBond hydroxy trace minerals have a positive effect on reproductive perfomance. Trials have shown that embryo quality is significantly improved and pregnancy rates of heifers and cows after artificial insemination are higher if they are fed IntelliBond hydroxy trace minerals.

Selko | Health and Fertility

The impact of trace mineral management on semen quality of bulls

Bulls supplemented with IntelliBond hydroxy trace minerals produced sperm with greater progressive motility, and greater sperm concentration. Cu and Zn hydroxychloride contained within IntelliBond are more bioavailable and more readily stored within the animal compared with Cu and Zn sulfate, resulting in an improvement of sperm quality of breeding bulls.

Selko | Health and Fertility

Improving fertility of your dairy herd

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Dairy Performance

Breeding for feed efficiency increases utilisation of roughage intake of dairy cattle

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Improve your silage making procedures to preserve the nutritional value of your silage for cows

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Health and Fertility

New Fusarium mycotoxins are emerging in dairy cows

Newly emergingmycotoxins of dairy cattle are neither routinely determined, nor legislatively regulated. However, the incidence of fusarium mycotoxins problems in ruminants is rapidly increasing. Watch the webinar of Professor Antonio Gallo about the impact of fusarium produced mycotoxins on the performance of dairy cows and a recent research update on mitigation strategies for mycotoxicosis. It includes the impact of mycotoxins on milk quality of dairy cattle.
Health and Fertility

Strategies to manage mycotoxin risk in dairy cows

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The impact of mycotoxins in dairy on health and performance

Impact of mycotoxins in cattle feed, how to assess the risk of mycotoxins in dairy and how to diagnose mycotoxins symptoms in cattle.

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DAIRY PERFORMANCE

The impact of trace mineral management on rumen function of dairy cows

During the EAAP congress, Professor Spears will discuss research that indicates that hydroxy sources of Zn and Cu are metabolized differently in the rumen than sulfate sources. This have an impact on fiber digestibility of dairy cattle.Limited research suggests that trace mineral source may affect the rumen microbiome of dairy cows.
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Making sustainable dairy farming more profitable

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IntelliBond’s increased bioavailability and the positive impact on fibre digestion and gut barrier function support well-being and optimizes animal productivity of dairy cows.

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Selko | LactiBute

Adding Selko LactiBute to the ration increases milk production while increasing fat and protein levels at the same time. This results in an increase of Energy Corrected Milk of 0.85-1 kg per head per day.

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Adding Selko Fytera Balance to the ration of dairy cattle increases milk production while reducing emission of enteric methane at the same time. This reduces the dairy carbon footprint per kg of milk produced by dairy cows.

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Selko TMR® is a blend of organic acids that reduces the growth of yeasts, moulds and bacteria such as Enterobacteriaceae like Salmonella. As a result of the reduction in growth of micro-organisms, increases in temperature of the TMR are delayed by at least 6 hours in silages treated with Selko-TMR, resulting in a higher dry matter intake.

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Selko | Renergy®

Selko Renergy® is a blend of organic acids that modifies rumen fermentation by increasing propionate production. Propionate is a key source of energy for ruminants and is also the most efficient volatile fatty acid (VFA) produced in the rumen. More energy from propionate in the rumen increases production efficiency.

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Selko | NutriCool

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Selko TOXO

Selko Toxo® is a mycotoxin mitigation product for dairy cows that contains a mycotoxin binder, bentonite with at least 50% smectite, which has strong binding capacity for aflatoxins, ergot toxines and LPS. It also contains glucose biopolymers which improve gut wall protection by maintaining tight junctions. This reduces the uptake of mycotoxins into the blood stream of dairy cows.

Read more   

Selko | TOXO-XL

Selko Toxo-XL® is a mycotoxin mitigation product for dairy cattle. It contains bentonite with at least 50% smectite, which has strong binding capacity for aflatoxins, ergot toxines and LPS, glucose biopolymers which improve gut barrier function of dairy cows, reducing the uptake of mycotoxins in combination with purified β-glucans that improve the immune function of dairy cows.

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